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IPF research: Let’s reimagine your path forward

Join a clinical study focused on the future of idiopathic pulmonary fibrosis treatment

The SURPASS-IPF Study is a clinical research study comparing an investigational product with a medication approved for people living with idiopathic pulmonary fibrosis (IPF). The study aims to see if the investigational product might slow the progression of IPF more than the approved medication, and to see how safe it is.

People who take part may receive*:

  • Study-related care from local doctors at no cost
  • Study drug at no cost

A short questionnaire helps identify if you may be a match. Final eligibility will be checked at a visit to a nearby study center.

Desktop - IconAbout the SURPASS-IPF Study

What is the SURPASS-IPF Study?

The SURPASS-IPF Study is a clinical research study (also called a “clinical trial”) for people living with idiopathic pulmonary fibrosis (IPF). The study will compare an investigational product with an approved medication for people living with IPF. The study aims to see:

  • if the investigational product might slow the progression of IPF more than the approved medication
  • how safe the investigational product is.

Participants will have an equal chance of receiving either the investigational product or the approved medication (both called the “study drug”).

The study at a glance:

  • Participants will be in the study for at least 1 year and 2 months, and for up to 3 years and 2 months, depending on when they join
  • Everyone in the study will receive the study drug for at least 1 year
  • Participants will have up to 21 study center visits
  • The study drug comes in capsules taken by mouth 3 times a day
  • About 1082 adults are expected to take part.
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What to expect

Before joining the study, you will first complete a short online questionnaire. If you are a potential match, you will be invited for a full eligibility check at a study center to see if the study is right for you

If you are eligible, you will visit the study center up to 21 times throughout the study. There will also be times when you will speak to the study team by phone. Several tests and assessments will be performed to monitor your health. These will include:

  • questionnaires and interviews about your health
  • physical examinations
  • measurements of vital signs (such as blood pressure and heart rate)
  • spirometry (a test that checks how your lungs are functioning)
  • electrocardiogram (ECG) to check your heart’s rhythm and activity
  • blood and urine tests
  • pregnancy tests (if applicable).

Some participants may also have additional, optional blood tests

fact_check (1)The study periods

 

The SURPASS-IPF Study is split into 3 periods: a screening period, a study treatment period, and a follow-up period.

 

How Does It Work Step 1

Screening period
(6 weeks)

  • You will have tests and assessments to see if you are eligible and the study is right for you.

How Does It Work Step 2

Study treatment period

This period will be split into 2 parts: Period 1 and Period 2. Everyone will join Period 1. Whether you join Period 2 depends on when you join the study.

Period 1
(at least 1 year)

  • You will take the study drug 3 times a day, every day
  • You will visit the study center about 10 times for study assessments.

Period 2
(up to 2 years)

  • You will enter Period 2 once you have completed a full year (52 weeks) of taking the study drug.
  • If you are in this period when the study ends, you will attend an end-of-treatment visit where you may have the option to receive the investigational product in an open-label extension (OLE) study.

How Does It Work Step 3 adults

Follow-up period
(about 4 weeks)

  • If you do not join the OLE study, you will attend an end-of-study visit for study tests and assessments about 4 weeks after you stop taking the study drug.
Who can take partWho Can Take Part?
To be eligible to join the SURPASS-IPF Study, you must:
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be 40 years of age or older
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have been diagnosed with IPF
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have not been treated with pirfenidone.
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Please note: You must meet all other study criteria during the full eligibility check at a study center to take part in the SURPASS-IPF Study.
Frequently Asked Questions (FAQs)

A clinical research study, also called a clinical trial or research study, is a carefully designed scientific evaluation of a potential new (investigational) product. Clinical research studies are conducted by doctors and researchers. A clinical research study helps to answer important questions about a potential new product, such as:

  • How safe is the potential new product?
  • Does it work?

A potential new (investigational) product, also sometimes called an investigational drug or a study medication, has been tested in a laboratory. Based on those results, it has been approved by health regulatory authorities for testing in people. An investigational product also may be a medication that is approved for the treatment of one disease or condition but is still under investigation in other diseases or conditions. An investigational product can only be used in clinical research studies.

All potential new products must be tested in clinical research studies before they can be approved by health regulatory authorities to be prescribed to patients. We need people to take part in clinical research studies so that new products can be developed.

There are always risks and benefits of participating in a clinical research study. There is always a chance that the potential new (investigational) product could cause side effects or will not work. However, you should know that there are strict rules in place to monitor the safety of people taking part in a study. Before joining any clinical research study, it is important to consider the risks and understand them.

The study team will explain all the risks and benefits at the first study visit. Throughout the study, a team of doctors and nurses will monitor the health of the people taking part. They will be there to answer any questions you may have.

The study-required potential new (investigational) product will be provided at no cost. The person taking part in the study will also receive study-related care from a team of experienced doctors and nurses throughout the study at no cost.

All personal information will remain confidential, and data will only be collected and used as necessary to support an individual’s match to and participation in a study. Participants’ names will not be included in any data reported. For more information, including how and why we process personal data, please read our Privacy Policy.

Clinical research studies must undergo rigorous reviews and follow strict rules. These rules help to ensure that the rights, safety, and well-being of participants are at the forefront of any study.

Participating in a clinical research study comes with risks as well as benefits. Before joining a study, potential participants must make sure they understand the benefits, such as getting access to study-related medical care and maybe helping others in the future. They must also understand the risks, such as unknown side effects. Potential study participants can take as much time as they need to decide whether to take part and get as much information as they can. Before joining a study, the potential study participant will be asked to sign an informed consent form, which will include a full explanation of the study, including its potential risks.

It is a personal decision to take part. Participation in the study is voluntary. Please also consider:

  • If a decision is made to participate, you can withdraw at any time during the study.
  • The study team will explain the possible benefits and risks of the study during the informed consent process.
  • A person does not have to join any study if they don’t want to.
  • A team of doctors and nurses will carefully monitor the health of people taking part during the study.
  • The potential new (investigational) product will be provided at no cost.
  • Taking part in the study may help other people with IPF in the future.

People taking part in the study will need to follow all the instructions from the study doctor and nurses.

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Discover If You Could be Eligible

Please answer the following questions to see if the study is a potential match. If you pre-qualify, we’ll see if there is a local study center available that will further check your eligibility. Additional criteria will apply.

You do not have to answer these questions, or take part in the study. If you come to a question you do not wish to answer, please close the web page.